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BreEStim for Post-Stroke Motor Recovery

BreEStim for Motor Recovery in Chronic Stroke With Moderate Impairment (Pilot).

Who can join

Ages 18 to 75 · All sexes

Inclusion criteria:

* has post stroke ≥ 6 months , medically stable;
* Unilateral, single stroke (no restriction on type (ischemic or hemorrhagic) or volume (large or small) of stroke);
* MAS score ≥ 1, i.e., detectable finger flexor hypertonia;

Exclusion criteria include:

* Patients with visual deficit/neglect; hearing or cognitive impairment;
* Patients with history of pulmonary disease (Asthma, chronic obstruction pulmonary disease, COPD);
* Patients that are currently adjusting tone alternating medications (e.g., baclofen), or
* Patients received botulinum toxin injection to the arm/fingers \<4 months, or phenol injections \< 2 years;
* Patients with a pacemaker;
* Women who are pregnant.

About the study

The overall goal is to investigate the effectiveness of a novel intervention - Breathing-controlled electrical stimulation (BreEStim) on finger flexor spasticity reduction and hand function improvement in chronic stroke with moderate impairment.

What is being tested

• BreEStim (device)
• EStim (device)

Sponsor: The University of Texas Health Science Center, Houston · Participants: 4 · Started: Nov 1, 2025

Contact the study team

• Sheng Li, MD, PhD · Phone: (713) 797-7125
• Shengai Li, MS · Phone: 713-797-7561

Official record on ClinicalTrials.gov — NCT04750551

Locations in the U.S.

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.