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Detection of Small Fiber Neuropathy Using Skin Properties

Who can join

Ages 18 and older · All sexes

Inclusion Criteria:

* Patients with age 18 year or older
* Patients that sign the informed consent form to participate in this study
* Patients completed the autonomic testing with skin biopsies

Exclusion Criteria:

* Patients with significant hairs at the legs that will cover the skin
* Any dermatological disorder that can affect the skin composition
* The use of skin lotion

About the study

Small fiber neuropathy affects millions of peoples worldwide. The neuropathy is causing disabling burning pain and dysautonomia such as dizziness with standing, brain fog, fatigue, constipation, too much or too little sweating. The detection of nerve damage is complicated and not widely available; it requires either skin biopsy or specialized equipment and training. This project utilizes the mathematical processing of skin pictures for the purpose to extract the statistical features related to loss of small fibers. This approach can improve the availability of diagnosis of small fiber neuropathy.

What is being tested

• Image processing of skin (other)

Sponsor: Brigham and Women's Hospital · Participants: 400 · Started: Jul 1, 2021

Contact the study team

• Peter Novak, MD · Phone: 617-732-7432

Official record on ClinicalTrials.gov — NCT04759443

Locations in the U.S.

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.