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Association of Periodontal Inflammation on Immune Response in Wound Healing

RecruitingObservational studyHealthy volunteers welcome

Who can join

Ages 21 to 70 · All sexes · Healthy volunteers welcome

Full eligibility criteria
Inclusion Criteria:

* non-restorable posterior tooth (molar/premolar) in need of extraction

Exclusion Criteria:

* systemic disease that effects inflammation

About the study

Subjects who are in need of extraction of a posterior tooth will be recruited for this study. Prior to extraction, periodontal clinical markers of inflammation, body-mass index and dental radiographs will be measured/taken. The posterior tooth will be atraumatically extracted and a small soft tissue biopsy of the extraction site will be taken. At the two week follow-up, sutures will be removed and another small biopsy of soft tissue will be taken. Subjects will be seen again at 3 months for a final collection of clinical data and radiographs.

What is being tested

Sponsor: University of Nebraska · Participants: 25 · Started: Sep 1, 2021

Contact the study team

Official record on ClinicalTrials.gov — NCT04805320

Locations in the U.S.

NebraskaUniversity of Nebraska, College of Dentistry, Lincoln

Conditions

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.