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Cognition and Motor Learning Post-stroke
Cognition as a Moderator of Motor Learning Post-stroke
Who can join
Ages 45 to 85 · All sexes
Full eligibility criteria
Inclusion Criteria: * Unilateral stroke * Stroke occurred more than 6 months prior * Paresis confined to one side * Independently ambulatory (including the use of assistive devices) * Able to walk for 5 minutes without stopping * Answers no to all general health questions on the PAR-Q+ * Willingness to complete study procedures Exclusion Criteria: * Brainstem or cerebellar stroke * Aphasia (expressive, receptive, or global) * Any major musculoskeletal or non-stroke neurological condition that interferes with the assessment of sensorimotor or cognitive function * Metal in the head (except in the mouth), implanted cranial or thoracic devices that violate MRI safety regulations * Uncontrolled hypertension (\>160/110mmHg) * Concurrent physical therapy * Claustrophobia * Significant cognitive deficit or dementia (\<20 on MoCA) * Inability to give informed consent
About the study
This project seeks to determine how post-stroke cognitive impairment moderates motor learning during walking in older adults with chronic stroke and identify brain structural markers that mediate this relationship. The chosen experimental design integrates biomechanical analyses, neuropsychological assessments, and brain imaging techniques to determine the impact of post-stroke cognitive impairment severity on two forms of motor learning (explicit and implicit) and examine the role of the dorsolateral prefrontal cortex in the relationship between cognition and explicit motor learning. Ultimately, this work may lead to the development of a more comprehensive, effective treatment approach to improve walking dysfunction in older adults post-stroke.
What is being tested
- Explicit motor learning (behavioral)
- Implicit motor learning (behavioral)
Sponsor: University of Southern California · Participants: 65 · Started: Jan 16, 2023
Contact the study team
- Kristan Leech, PT, DPT, PhD · Phone: (323) 442-1583
- Sarah Kettlety, MS · Phone: (323) 442-1196
Official record on ClinicalTrials.gov — NCT04829071
Locations in the U.S.
| California | Center for Health Professions, Los Angeles |
Conditions
From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.