Neurofeedback Intervention for Reading Deficits in Subacute Stroke
Rehabilitation of Reading Deficits in Subacute Stroke Using Functional Magnetic Resonance Imaging (fMRI) Neurofeedback and Motor Imagery
Who can join
Ages 18 to 80 · All sexes · Healthy volunteers welcome
Full eligibility criteria
Inclusion Criteria: * First-ever left-hemisphere stroke \< 3 months prior to study recruitment or healthy volunteer * Age: 18 - 80 years old * Fluent and literate in English prior to stroke * Reading deficits, defined as \>3 errors on the Paragraphs test (subtests VIII, IX) of the Reading Comprehension Battery for Aphasia-2nd ed. (RCBA-2) in keeping with the healthy control accuracy criterion of 86-100% correct. Exclusion Criteria: * Inability to consent or complete study tasks * Inability to undergo MRI (e.g., pregnancy, non-MRI compatible implants, claustrophobia) * A history of prior neurological disease (e.g., brain tumor, Alzheimer's disease)
About the study
The overall goal of this project is to advance a biologically-based approach to treatment of reading disorders after stroke, which will expand the limits of cognitive rehabilitation. Using a novel brain imaging technique, called real-time functional magnetic resonance imaging (fMRI) neurofeedback combined with right hand motor imagery, this project will re-instate brain activity in the left language-dominant hemisphere. Stroke patients will practice modulating their own brain activity using fMRI neurofeedback signal and will select the most effective mental strategies that help them maintain brain activation patterns associated with better reading recovery.
What is being tested
- Motor Imagery and Real-Time fMRI Neurofeedback (behavioral)
- Motor Imagery and Sham fMRI Neurofeedback (behavioral)
Sponsor: Kessler Foundation · Participants: 28 · Started: Apr 3, 2023
Contact the study team
Official record on ClinicalTrials.gov — NCT04875936
Locations in the U.S.
| New Jersey | Kessler Foundation, West Orange |
Conditions
From ClinicalTrials.gov, data retrieved Oct 1, 2026. Each study sets its own eligibility; the study team decides who can join.