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Motor Training for Infants With Cerebral Palsy

Recruiting

Motor Training Intervention for Infants at High-Risk for Cerebral Palsy: Feasibility and Acceptability

Who can join

3 Months – 8 Months · All sexes

Full eligibility criteria
Inclusion Criteria:

* Age at enrollment: between 3-8 months corrected age
* Caregivers fluent in English
* Preterm infants with objectively defined severe diffuse white matter abnormality on MRI at term OR
* High-risk infants (e.g., preterm, neonatal hypoxic-ischemic encephalopathy, perinatal stroke) with moderate-severe injury on structural MRI or cranial ultrasound (e.g., basal ganglia/thalamic signal intensity, cystic periventricular leukomalacia, encephalomalacia, large stroke, and/or severe intraventricular/periventricular hemorrhage) at around term-equivalent age or before Neonatal Intensive Care Unit discharge AND either:

  * "Absent" fidgety movements based on the Prechtl General Movement Assessment (GMA) between 3-4 months corrected age OR
  * A score of 56 or below on the Hammersmith Infant Neuromotor Examination (HINE) between 3-6 months corrected age (31)

Exclusion Criteria:

* Medical conditions that restrict active participation such as oxygen dependence
* Infants with significant visual deficits defined by the inability to track an object horizontally
* Living in a remote location prohibiting drives to the hospital every other week.

About the study

The intervention in this study, Let's Move, is a motor intervention for infants at risk for cerebral palsy. We will test the feasibility and acceptability of the intervention as well as preliminary effectiveness.

What is being tested

Sponsor: Children's Hospital Medical Center, Cincinnati · Participants: 35 · Started: Jan 7, 2022

Contact the study team

Official record on ClinicalTrials.gov — NCT04886895

Locations in the U.S.

OhioCincinnati Children's Hospital Medical Center, Cincinnati

Conditions

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.