Home › Metabolic Bone Diseases › NCT04954664
Ridge Augmentation Using Allograft Particles Hydrated With or Without Recombinant Human Platelet-Derived Growth Factor
Lateral Ridge Augmentation Using Allograft Bone Particles Hydrated With or Without Recombinant Human Platelet-Derived Growth Factor: A Clinical and Histological Randomized Controlled Trial
Who can join
Ages 18 to 99 · All sexes · Healthy volunteers welcome
Full eligibility criteria
Inclusion Criteria: * English speaking * At least 18 years old * Must be a patient of the UAB Dental School * Able to read and understand informed consent document * Need for implants to replace missing tooth or teeth in at least one quadrant of the mouth. * Insufficient alveolar ridge width for endosseous implant placement defined as 5mm or less as determined by bone sounding and cone beam computed tomography (CBCT) scan. Exclusion Criteria: * Non-English speaking * Less than 18 years old * Smokers/tobacco users (\>10 cigarettes/day) * Patients with systemic pathologies or conditions contraindicating oral surgical procedures or adversely affecting wound healing * Patient is a poor compliance risk (i.e., poor oral hygiene, history of alcohol or drug abuse) * Vertical loss of bone at edentulous ridge.
About the study
This study will compare two techniques to achieve increase in ridge dimensions as a preparation for dental implants using a resorbable barrier membrane and bone particulate allogenic graft hydrated with saline or a growth factor called Recombinant Human Platelet-Derived Growth Factor (rhPDGF).
What is being tested
- Allograft particles hydrated with rhPDGF (biological)
- Allograft particles hydrated in a conventional way with saline. (biological)
Sponsor: University of Alabama at Birmingham · Participants: 44 · Started: Aug 11, 2021
Contact the study team
- Hussein Basma, DDS, MS · Phone: 205-934-2888
- Sarah Startley, DMD · Phone: 205-975-8711
Official record on ClinicalTrials.gov — NCT04954664
Locations in the U.S.
| Alabama | Unversity of Alabama at Birmingham, School of Dentistry, Birmingham |
Conditions
From ClinicalTrials.gov, data retrieved Oct 2, 2026. Each study sets its own eligibility; the study team decides who can join.