Home › Parathyroid Cancer › NCT04969926

Natural History Study of Parathyroid Disorders

Who can join

6 Months – 100 Years · All sexes

* INCLUSION CRITERIA:

In order to be eligible to participate in this study, an individual must meet all of the following criteria:

* Subjects known to have, suspected of having, or at risk of developing a parathyroid or related disorder.
* Age \>= 6 months.

EXCLUSION CRITERIA:

An individual who meets any of the following criteria will be excluded from participation in this study:

* Children \<= 6 months
* Patients with conditions that in the opinion of the investigators can interfere with the study objectives.

About the study

Background:

Parathyroid disorders are very common in the general population and include disorders of parathyroid excess, deficiency, or defects in parathyroid hormone (PTH) signaling. PTH, the main secretory product of parathyroid glands is responsible for regulation of calcium-phosphate homeostasis.

Objective:

i) To investigate the cause of parathyroid disorders

ii) To describe evolution, natural history, and longitudinal trends of parathyroid and related disorders seen in syndromic presentations like multiple endocrine neoplasia, hyperparathyroidism-jaw tumor syndrome

Eligibility:

People ages 6 months older who have, are at risk of having, or are related to a person with a parathyroid or related disorder.

Design:

Participants will be screened with a review of their medical records.

Participants will be seen, tested, and treated by doctors based on their condition. Their visits may be in person or via telehealth.

Participants will complete questionnaires. They will answer questions about their physical, mental, and social health.

Participants may give samples such as saliva, blood, urine, or stool.

Participants may give cheek cell samples. They will do this using a cheek swab or by spitting into a cup.

Adult participants may give a skin biopsy. For this, a small bit of skin is removed with a punch tool.

Participants may have medical photos taken.

If participants have surgery during the course of their regular care either at the NIH

or at a different hospital or doctor s office, researchers will ask for some of the leftover

tissue.

Participants will be in the study as long as they are being seen by their doctor.

Sponsor: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) · Participants: 3,000 · Started: Nov 30, 2021

Contact the study team

• Lynn M Bliss · Phone: (301) 435-7921
• Smita Jha, M.D. · Phone: (301) 827-1930

Official record on ClinicalTrials.gov — NCT04969926

Locations in the U.S.

Conditions

• Parathyroid Cancer
• Primary Hyperparathyroidism

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.