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A Randomized Trial of a Mobile Health Exercise Intervention for Older Adults With Myeloid Neoplasms
A Pilot Randomized Trial of a Mobile Health Exercise Intervention for Older Patients With Myeloid Neoplasms
Who can join
Ages 60 and older · All sexes
Full eligibility criteria
Inclusion Criteria: * Age ≥60 years (conventional definition of older age in clinical trials of MN) * Have a diagnosis of MN * Planned for or receiving outpatient cancer-directed treatments (participants receiving consolidative or maintenance outpatient therapies after induction chemotherapy are allowed to enroll) * English speaking * Eastern Cooperative Oncology Group (ECOG) performance status of 0-3 * No medical contraindications for exercise per oncologist * Able to walk 4 meters as part of Short Physical Performance Battery measured walk (with or without assistive device) * Able to provide informed consent Exclusion Criteria: * Physical, psychological, or social impairments that would interfere with subject's ability to participate in the study or participate in the intervention, as determined by the PI or the treating team
About the study
This is a phase 2 randomized controlled trial (RCT) to assess the preliminary efficacy of the a mobile health exercise intervention (GO-EXCAP) versus a chemotherapy education control in 100 older patients with MN receiving outpatient chemotherapy on physical function and patient-reported outcomes (fatigue, mood, and quality of life). We will also explore the effect of the intervention on TNFα and related cytokine gene promoter methylation and their gene and protein expression.
What is being tested
- GO-EXCAP Mobile App (behavioral)
- Behavioral Placebo Control (behavioral)
Sponsor: University of Rochester · Participants: 170 · Started: Jan 3, 2022
Contact the study team
- Kah Poh Loh · Phone: 585-275-5863
- Becky Gravenstede · Phone: 585-727-4728
Official record on ClinicalTrials.gov — NCT04981821
Locations in the U.S.
| New York | University of Rochester Medical Center/Wilmot Cancer Institute, Rochester |
Conditions
From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.