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Laser Photocoagulation of Communicating Vessels in Twin-to-Twin Transfusion Syndrome

Laser Photocoagulation of Communicating Vessels in Twin-to-Twin Transfusion Syndrome (TTTS)

Who can join

All ages · Women

Inclusion Criteria:

* Single placenta (Monochorionic)
* Polyhydramnios present in recipient twin (Greater than 8 cm maximum vertical pocket below 20 weeks and greater than a 10 cm pocket for greater than 20 weeks gestational age)
* Oligohydramnios present in donor twin (Less than 2 cm maximum vertical pocket)
* Prominent bladder in the recipient/ non-filling bladder in the donor
* Thin dividing membrane

Exclusion Criteria:

* Patients unwilling to participate in the study or to be followed up
* Presence of major congenital anomalies incompatible with survival
* Active pre-term labor Ruptured membranes
* Chorioamnionitis
* Vaginal bleeding

About the study

The purpose of this study is to evaluate the use of diode laser photocoagulation of the communicating vessels in twin-to- twin transfusion syndrome (TTTS) with respect to maternal, fetal and neonatal outcomes.

What is being tested

• Fetoscopic laser ablation (procedure)

Sponsor: Seattle Children's Hospital · Participants: 2,000 · Started: Oct 1, 2021

Contact the study team

• Martin P Walker, MD · Phone: 206-987-3539
• Melissa Dorn, RN MN · Phone: 206-987-4137

Official record on ClinicalTrials.gov — NCT05008744

Locations in the U.S.

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.