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Baby Brain Recovery Study
Perinatal Stroke: Longitudinal Assessment of Infant Brain Organization and Recovery Through Neuroexcitability, Neuroimaging and Motor Development
Who can join
0 Years – 24 Months · All sexes
Full eligibility criteria
Main Inclusion Criteria: * Infants with corrected gestational age between term age and 24 months of age at study enrollment * Radiologically-confirmed acute unilateral or bilateral brain lesions, including perinatal stroke, neonatal hemorrhagic or thrombotic stroke, involving the motor cortex and/or subcortical structures, and intracranial hemorrhage, involving the motor cortex and/or subcortical white matter, periventricular leukomalacia, and hypoxic-ischemic encephalopathy (HIE) * English-speaking parent/legal guardian (able to provide consent) Main Exclusion Criteria: * Other neurologic disorders unrelated to perinatal stroke/brain bleed/HIE * Metabolic disorders * Disorders of Cellular Migration and Proliferation * Acquired Traumatic Brain Injury
About the study
This study will be a longitudinal multiple-visit observational study, done to identify possible bioindicators of recovery and repair of motor corticospinal pathways which may be targeted by future interventions in infants with perinatal stroke.
65 participants will be recruited and complete 1 visit at time point 1 (0-2 months), and 2 visits at each timepoints 2-5 with windows of +- 4 weeks (3-6 months, 12 months, 18 months and 24 months). Visits will consist of Magnetic Resonance Imaging (MRI) assessment during the child's natural sleep, Transcranial Magnetic Stimulation (TMS), and Motor Behavioral Assessments.
What is being tested
- Magnetic Resonance Imaging (device)
- Behavioral Assessments (behavioral)
- Non invasive Transcranial Magnetic Stimulation (device)
Sponsor: University of Wisconsin, Madison · Participants: 65 · Started: Jul 26, 2022
Contact the study team
- Bernadette Gillick, PhD, MSPT · Phone: 608-262-3079
Official record on ClinicalTrials.gov — NCT05013736
Locations in the U.S.
| Wisconsin | University of Wisconsin School of Medicine and Public Health, Madison |
Conditions
From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.