Home › Postoperative Hemorrhage › NCT05047133

Effect of Early Administration of TXA in Adult Hip Fractures

Does Early Administration of Tranexamic Acid Decrease Perioperative Blood Loss in Addition to Intraoperative Tranexamic Acid for Hip Fracture Patients?

Who can join

Ages 18 and older · All sexes · Healthy volunteers welcome

Inclusion Criteria:

* 1\. All adult (18 years old or older) hip fracture patients presenting with an acute hip fracture and undergoing operative fixation

Exclusion Criteria:

1. Polytrauma patients
2. Previous operation on the ipsilateral hip
3. Patients with coagulopathies (Factor V Leiden, Sickle Cell Anemia, Etc.)
4. Patients with \< 6-month history of thromboembolic event (DVT/PE), Stroke, Cardiac Stents, or Myocardial Infarction (MI)
5. History of seizure disorder
6. Patients on birth control
7. Pregnant Women
8. Prisoners
9. Active thromboembolic disease (DVT/PE, MI, Stroke)

About the study

This is a prospective clinical study designed to assess blood loss in intracapsular and extracapsular hip fractures undergoing operative fixation at a Level II trauma center. It is well established in the orthopedic literature that tranexamic acid (TXA) decreases blood loss and need for postoperative blood transfusion in hip fracture patients as well as total joint arthroplasty patients. A typical dosing pattern, and the dosing pattern employed at our institution, is 1 gram IV infused prior to incision followed by 1 gram IV infused at the time of wound closure.

What is being tested

• Tranexamic acid (drug)

Sponsor: Ascension Health · Participants: 170 · Started: Sep 1, 2021

Contact the study team

• Jacob Hinkley, DO, MS · Phone: 810-606-5669
• Jacob Lytle, DO · Phone: 810-606-5669

Official record on ClinicalTrials.gov — NCT05047133

Locations in the U.S.

Conditions

• Postoperative Hemorrhage

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.