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DISE: Phenotyping Obstruction Patterns
Drug-Induced Sleep Endoscopy (DISE): Phenotyping Obstruction Patterns
Who can join
Ages 18 and older · All sexes
Full eligibility criteria
Inclusion Criteria: 1. Adults (≥ 18yrs) willing and capable of providing informed consent. 2. English-speaking \& able to give Informed Consent. 3. Referred or scheduled for clinically indicated DISE procedure. 4. Seeking CPAP alternatives for treatment of sleep disordered breathing. Exclusion Criteria: * None
About the study
Drug-induced sleep endoscopy (DISE) represents an opportunity to evaluate the upper airway in sleep-like conditions. In its current clinical form, however, DISE does not routinely determine the functional impact of anatomic and neuromuscular factors on airflow obstruction.
The investigators will apply nasal pressure (CPAP) during DISE to generate pressure-flow and pressure-area relationships, deriving functional determinants of upper airway obstruction during sleep. In addition, they will use objective anatomic measurements from computerized tomography (CT) and submental ultrasound. The findings will allow the investigators to streamline the upper airway exam during DISE, and will further the goal of developing personalized solutions that address specific pathogenic mechanisms of pharyngeal collapse and airflow obstruction during sleep.
The investigators will use the physiologic and anatomic features derived from DISE and imaging to determine which are predictive of success to standard-of-care surgical interventions (e.g. skeletal, soft tissue, neurostimulation) .
What is being tested
- Pharyngeal Manometry (other)
- Submental Ultrasound (other)
Sponsor: University of Pennsylvania · Participants: 241 · Started: Nov 12, 2021
Contact the study team
- Everett Seay · Phone: 2156158777
- Erica Kent · Phone: 2156158777
Official record on ClinicalTrials.gov — NCT05050383
Locations in the U.S.
| Pennsylvania | University of Pennsylvania, Philadelphia |
Conditions
From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.