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Comparison of Synthetic Mammography Versus Full-Field Digital Mammography in Image Interpretation and Performance Metrics

RecruitingObservational study

Who can join

Ages 18 and older · Women

Full eligibility criteria
Inclusion Criteria:

* Female
* Age 18 or older
* Consecutive cases in breast imaging center

Exclusion Criteria:

* Cases demonstrate administrative or technical errors (e.g. missing views, labeling inconsistent with report, etc.)

About the study

This study compares synthetic mammography to full-field digital mammography in image interpretation and performance metrics. Digital breast tomosynthesis (DBT) has previously been found to be superior in performance to standard digital mammography in both screening and diagnostic settings for the early detection and improved diagnosis of breast cancers. DBT in combination with full-field digital mammography (FFDM) reduces recall rates and increases cancer detection rates relative to FFDM alone. Synthetic mammography is a 2-dimensional reconstructed image, using the dataset derived from the DBT acquisition, without requiring additional radiation dose. Collecting information from patients' medical records may help doctors analyze the characteristics, utility, and impact of synthetic mammography to compared to FFDM.

What is being tested

Sponsor: M.D. Anderson Cancer Center · Participants: 750 · Started: Dec 15, 2020

Contact the study team

Official record on ClinicalTrials.gov — NCT05056818

Locations in the U.S.

TexasM D Anderson Cancer Center, Houston

Conditions

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.