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Effectiveness of Aquamin® in Mitigating Halitosis

RecruitingPhase 2Healthy volunteers welcome

Evaluation of Halitosis Using a Multi-Mineral Approach (Aquamin®)

Who can join

Ages 18 to 99 · All sexes · Healthy volunteers welcome

Full eligibility criteria
Inclusion Criteria:

* Must be able to give written informed consent
* Willing to follow study procedures of no eating, drinking, toothbrushing, smoking or using mouth rinse 60 minutes before study visits
* Have stable oral health
* Self-reported halitosis
* A negative pregnancy test for pre-menopausal women with intact female reproductive organs, and the subject must agree to use appropriate birth control over the study period.

Exclusion Criteria:

* Pregnant or lactating women
* Participating in any other interventional trials using an investigational drug
* Diagnosed with any stomach or intestinal bleeding disorders (gastrointestinal bleeding from gastric or duodenal ulcers, or gastrin-secreting tumors) or active gastric/duodenal ulcers - peptic ulcer disease (in last 3 months) or with severe symptoms of ulcerative colitis or Crohn's disease
* Any gastrointestinal or colonic malignancy; kidney disease, including kidney "stones" or hypercalcemia
* Coagulopathy/hereditary hemorrhagic disorders/or receiving therapeutic doses of Coumadin or heparin
* Have any severe oral condition that, in the opinion of the oral healthcare provide might impact the results of the study if the condition is treated
* Have been treated for oral cancer within the past year
* Taking any of the following within 30 days (will be eligible after completing 30 days of washout period):

Calcium; Vitamin D, including multivitamins that have low amounts of calcium/Vitamin D supplements; Oral steroids; Non-steroidal anti-inflammatory medications (NSAIDS); Antibiotics.

About the study

The purpose of this study is to assess whether Aquamin®, a multi-mineral natural product from red marine algae, can help reduce halitosis when taken for 90 days.

What is being tested

Sponsor: University of Michigan · Participants: 25 · Started: Aug 15, 2022

Contact the study team

Official record on ClinicalTrials.gov — NCT05058638

Locations in the U.S.

MichiganUniversity of Michigan School of Dentistry, Ann Arbor

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.