Locomotor Recovery and Compensation Post-stroke (LRC)
Who can join
Ages 18 to 85 · All sexes
Full eligibility criteria
Inclusion criteria: * individuals early post-stroke (\<15-30 days) * first ever stroke * unilateral hemiparesis * currently receiving inpatient rehabilitation * ability to follow 1-step commands * provision of informed consent * medical clearance from the rehabilitation physician to participate. \\ Exclusion criteria: * uncontrolled cardiovascular, metabolic or respiratory disease that limits exercise participation (e.g., congestive heart failure, resting blood pressure \> 200/110 mmHg, uncontrolled diabetes, end-stage renal disease) * absolute criteria for termination of exercise testing during initial and repeated ECG testing during graded exercise testing using ACSM guidelines . * other orthopedic or neurological disorder that limited walking prior to stroke
About the study
The proposed research will characterize of the time course of neurological and locomotor recovery as well as development of compensatory strategies throughout sub-acute and chronic phases post stroke. In addition, we will also investigate the extent to which measures of recovery and compensation are malleable and can be altered with specific interventions in both the early and late stages post-stroke. Delineation of the time course of development and magnitude of patterns of recovery and compensation should result in alternative predictive "rules' regarding how patients early post-stroke could recovery functional and neurological function.
What is being tested
- high-intensity training focused on stepping in variable contexts (behavioral)
Sponsor: Indiana University · Participants: 150 · Started: Sep 1, 2021
Contact the study team
- Thomas G Hornby · Phone: 3173292353
- Chris Henderson · Phone: 3173292353
Official record on ClinicalTrials.gov — NCT05081713
Locations in the U.S.
| Indiana | Rehabilitation Hospital of Indiana, Indianapolis |
Conditions
From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.