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Cerebellar Stimulation for Aphasia Rehabilitation
Recruiting
Who can join
Ages 18 to 99 · All sexes
Full eligibility criteria
Inclusion Criteria: * Chronic ischemic or hemorrhagic left hemisphere stroke * Fluent speaker of English by self-report * Age 18 or older * 6 months post onset of stroke * Diagnosis of aphasia and naming impairment using the Western Aphasia Battery-Revised Exclusion Criteria: * Lesion in the right cerebellum * Previous neurological disorder (other than stroke) affecting the brain, or any other neurodegenerative disorder or psychiatric disorder * Seizures during the previous 6 months * Uncorrected visual loss or hearing loss by self-report * Use of medications that lower the seizure threshold (e.g., methylphenidate) * Use of N-methyl-D-aspartate (NMDA) antagonists (e.g., memantine) * History of brain surgery or any metal in the head * Severely impaired auditory comprehension (lower than 2 on the Comprehension subscore on the Western Aphasia Battery-Revised) * Severely limited verbal output (lower than 2 on the Spontaneous Speech rating scale on the Western Aphasia Battery-Revised) * Individuals with severe claustrophobia, cardiac pacemakers or ferromagnetic implants, and pregnant women will be excluded from the MRI portion of the study.
About the study
The optimal site of neuromodulation for post-stroke aphasia has yet to be established. This study will investigate whether multiple sessions of cerebellar transcranial direct current stimulation (tDCS) boosts language therapy in helping people recover from aphasia as well as predict who is likely to respond to cerebellar tDCS.
What is being tested
- Cathodal Cerebellar tDCS (device)
- Semantic Feature Analysis (SFA) (behavioral)
- Sham (device)
Sponsor: Johns Hopkins University · Participants: 60 · Started: Oct 25, 2021
Contact the study team
- Rajani Sebastian, PhD · Phone: 410-502-2445
- Becky Lammers, MS · Phone: 410-502-2445
Official record on ClinicalTrials.gov — NCT05093673
Locations in the U.S.
| Maryland | Johns Hopkins Hospital, Baltimore |
Conditions
From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.