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Muscle Blood Flow Regulation in HFpEF
Mechanisms of Impaired Skeletal Muscle Blood Flow and Exercise Intolerance in Veterans With Heart Failure With Preserved Ejection Fraction: Efficacy of Knee Extensor Training
Who can join
Ages 18 and older · All sexes · Healthy volunteers welcome
Full eligibility criteria
Inclusion Criteria: * Age 18 years or older and able to give written informed consent * New York Heart Association (NYHA) functional class II or III * Left Ventricular Ejection Fraction (LVEF) \> 50% * Plasma Brain Natriuretic Peptide (BNP) \>200 pg/mL or NT-proBNP 400 pg/mL at enrollment Exclusion Criteria: * Prior EF of \<50%. * NYHA Class IV or HF that cannot be stabilized on optimized pharmacotherapy * Acute coronary syndrome, infiltrative cardiomyopathy, or myocarditis * Patients with HFpEF secondary to significant uncorrected primary valvular disease (except mitral regurgitation secondary to left ventricular dysfunction) * Orthopedic limitations that would prohibit knee-extensor exercise * Women currently taking hormone replacement therapy (HRT) will be excluded from the proposed studies due to the direct vascular effects of HRT * Women who are pregnant or may become pregnant, but the typical age of female patients with HFpEF will be postmenopausal * Current smokers
About the study
Heart failure with preserved ejection (HFpEF) disproportionately affects Veterans and is the number one reason for hospital discharge in the VA Health Care System. Exercise intolerance is a common complication experienced by patients with HFpEF, perpetuating physical inactivity and accelerating disease progression. This research proposal aims to elucidate mechanisms responsible for inadequate skeletal muscle blood flow and exercise intolerance in patients with HFpEF compared with healthy controls as well as following 8 weeks of exercise training in patients with HFpEF only.
What is being tested
- Exercise training (other)
Sponsor: VA Office of Research and Development · Participants: 35 · Started: Jul 1, 2022
Contact the study team
- Kanokwan Bunsawat, PhD · Phone: (801) 582-1565
- David W Wray, PhD · Phone: (801) 582-1565
Official record on ClinicalTrials.gov — NCT05115890
Locations in the U.S.
| Utah | VA Salt Lake City Health Care System, Salt Lake City, UT, Salt Lake City |
From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.