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Micro/Nanobubbles (MNBs) for Treatment of Acute and Chronic Wounds

Micro/Nanobubbles (MNBs) and Wound Therapy: A Pilot Study Involving a Novel Oxygen Delivery System for Treatment of Acute and Chronic Wounds

Who can join

Ages 18 and older · All sexes

Inclusion Criteria:

* are above the age of 18.
* have traumatic, surgical, or chronic wounds.
* have radiotherapy related tissue injury.
* have thermal, chemical, and/or electrical burn injuries.
* have pressure ulcers, diabetic foot ulcers, venous ulcers, arterial ulcers, and/or neuropathic skin ulcers.
* have acute ischemic wounds

Exclusion Criteria:

* have infected wounds.
* have wounds with exposed vital structures such as nerves, arteries, and/or veins.
* have wounds associated with malignancy.

About the study

The purpose of this study is to assess the safety and efficacy of Micro/nanobubbles (MNB's) for the healing of acute and chronic wounds.

What is being tested

• Micro/nanobubble (MNB) - Irrigation (drug)
• 0.9% Normal Saline - Irrigation (other)
• Micro/nanobubble (MNB) - Negative Pressure Wound Therapy with Instillation (NPWTi) (drug)
• 0.9% Normal Saline - Negative Pressure Wound Therapy with Instillation (NPWTi) (other)

Sponsor: University of California, Irvine · Participants: 40 · Started: Oct 9, 2021

Contact the study team

• Leonardo Alaniz, BBA · Phone: 602-318-7118
• Lohrasb R Sayadi, MD · Phone: 949-209-7267

Official record on ClinicalTrials.gov — NCT05169814

Locations in the U.S.

From ClinicalTrials.gov, data retrieved Oct 1, 2026. Each study sets its own eligibility; the study team decides who can join.