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Study of Healthy Cohort for Early Detection of Cancer

Who can join

Ages 18 and older · All sexes

Inclusion Criteria:

* All adults 18 years of age of older undergoing upper or lower endoscopy for routine medical care.

Exclusion Criteria:

* Persons with current malignancy
* Persons with history of malignancy and treatment within last 5 years of enrollment, excluding non-melanoma skin cancer or cervical in-situ.
* Persons who are unable or unwilling to provide repeat blood samples and complete follow-up questionnaires
* Persons who lack the capacity to provide consent
* Persons who do not speak English
* Persons who are visually or hearing impaired.

About the study

Cancer produces a significant burden on society with a majority diagnosed at late stages when the chance of cure is low. Early diagnosis improves patient outcomes. Data consisting of lifestyle factors, medications, physical activity, years before conventional cancer diagnosis is also worthwhile for to determine early detection. This is only achievable with longitudinal tracking of a large number of healthy individuals and identifying those who do develop cancer over time.

Sponsor: Johns Hopkins University · Participants: 10,000 · Started: Feb 1, 2023

Contact the study team

• Elham Afghani · Phone: 410-955-5000

Official record on ClinicalTrials.gov — NCT05193305

Locations in the U.S.

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.