Sex Disparities in Hypoxic Vasodilation and Impact of Obesity
RecruitingEarly phase 1Healthy volunteers welcome
Who can join
Ages 18 to 45 · All sexes · Healthy volunteers welcome
Full eligibility criteria
Inclusion Criteria: * BMI \>18 kg/m2 Exclusion Criteria: * Pregnancy, breastfeeding * Diagnosed sleep apnea or AHI \>10 events/hr * Current smoking/Nicotine use * Increased risk of bleeding, pro-coagulant disorders, clotting disorders, anticoagulation therapy * Nerve/neurologic disease * Cardiovascular, hepatic, renal, respiratory disease * Blood pressure ≥140/90 mmHg * Diabetes, Polycystic ovarian syndrome * Communication barriers * Prescription medications, Sensitivity to lidocaine
About the study
The purpose of this project is to examine key mechanisms contributing to sex-differences in hypoxic vasodilation and the impact of obesity, with particular emphasis on the sympathetic nervous system.
What is being tested
- Propranolol Hydrochloride (drug)
- Isoproterenol (drug)
- Phentolamine Mesylate (drug)
- Norepinephrine (drug)
Sponsor: University of Missouri-Columbia · Participants: 72 · Started: Mar 14, 2023
Contact the study team
- Jacqueline K Limberg, Ph.D. · Phone: 5738822544
Official record on ClinicalTrials.gov — NCT05219799
Locations in the U.S.
| Missouri | University of Missouri, Columbia |
Conditions
From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.