Impact of Exercise on the Complications of Corticosteroids in Patients With GVHD: the RESTART Trial

Inclusion Criteria:

* Over 18 years old; children under the age of 18 will be excluded due to rarity of disease
* Newly diagnosed with acute or chronic GVHD, starting corticosteroids at a dose of .20 mg/kg or greater for the first time since transplant
* Received allogeneic stem cell transplant (any conditioning, any donor) at Dana-Farber Cancer Institute
* Physician's clearance to participate in moderate-vigorous intensity exercise
* Speak English
* Currently participate in less than 60 minutes of structured exercise/week
* Willing to travel to Dana-Farber Cancer Institute for necessary data collection
* Ability to understand and the willingness to sign a written informed consent document.

Exclusion Criteria:

* Have a plan for hospital admission within the next 13 weeks at the time of recruitment
* If patients are not enrolled within 14 days after initial steroid treatment, they will be ineligible
* Pre-existing musculoskeletal or cardiorespiratory conditions
* Patients should not have any uncontrolled illness including ongoing or active infection, uncontrolled diabetes, hypertension, or thyroid disease
* Patients may not be receiving any other investigational agents, or concurrent biological, chemotherapy, or radiation therapy
* Patients with other active malignancies
* Participate in more than 60 minutes of structured exercise/week
* Unable to travel to Dana-Farber Cancer Institute for necessary data collection
* Subjects, who in the opinion of the investigator, may not be able to comply with the safety monitoring requirements of the study.