Home › Tetralogy of Fallot › NCT05236153

Electroanatomic Interactions Between Transcatheter Pulmonary Valve Prostheses and Anatomic Isthmuses in Repaired Tetralogy of Fallot

Who can join

All ages · All sexes

Inclusion Criteria:

* Diagnosis of tetralogy of Fallot (TOF) or double outlet right ventricle (DORV)
* Referred for transcatheter pulmonary valve replacement (TPVR) per routine clinical indications
* Weight \>=25 kg

About the study

Individuals with repaired Tetralogy of Fallot (rTOF) remain at risk for sudden cardiac death from ventricular tachycardia (VT). Transcatheter pulmonary valve replacement (TPVR) indications continue to broaden, yet its capability to reduce the risk of VT and sudden cardiac death remains unknown. Thus, in a cohort of participants with rTOF who are presenting for TPVR the investigators intend to: (1) quantify and localize right ventricular (RV) isthmuses with abnormal voltage and/or conduction velocity; (2) identify which RV isthmuses are at risk of being "jailed" by TPV prostheses; and (3) explore the feasibility of omnipolar technology to characterize wavefront directionality and differentiate slow conduction from conduction block.

What is being tested

• Electroanatomic substrate mapping (diagnostic test)

Sponsor: Boston Children's Hospital · Participants: 60 · Started: Nov 4, 2022

Contact the study team

• Edward T O'Leary, MD · Phone: 617-355-7833

Official record on ClinicalTrials.gov — NCT05236153

Locations in the U.S.

Conditions

• Tetralogy of Fallot
• Ventricular Tachycardia
• Cardiac Sudden Death

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.