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Metabolic and Functional Consequences of Aging in Health and Disease

Who can join

Ages 50 and older · All sexes · Healthy volunteers welcome

Inclusion Criteria:

* Stable body-weight (± 5%) for the past 3 months
* Subject is judged to be in satisfactory health based on medical history, physical examination, and laboratory screening evaluations.
* Ability to walk, sit down and stand up independently or with walking mobility aids
* Ability to lie in a supine or elevated position for up to 3 hours
* Willingness and ability to comply with the protocol

Exclusion Criteria:

* Insulin dependent diabetes mellitus
* Established diagnosis of malignancy
* History of untreated metabolic diseases including hepatic or renal disorder
* Presence of acute illness or metabolically unstable chronic illness
* Presence of fever within the last 3 days
* Use of short course of oral corticosteroids within 4 weeks preceding study day
* Failure to give informed consent or Investigator's uncertainty about the willingness or ability of the subject to comply with the protocol requirements
* (Possible) pregnancy
* Already enrolled in another clinical trial and that clinical trial interferes with participating in this study

About the study

Considerable heterogeneity in the aging population has been observed. The exceptional longevity of individuals reaching 100 years old, so-called centenarians may be an example of life-long healthy aging, or added years may be spent in poor health with decreased physical and cognitive functioning. Current knowledge of the aging experience and the trajectories of physical and cognitive decline across various age groups are not well-understood, yet crucial to prevent spending added years in disease. Hence, the study objective is to develop the metabolic profile associated with aging-related disorders measured as the incidence of impaired functional capacity, cognitive function, and/or well-being.

What is being tested

• Stable tracer infusion in a postabsorptive state (other)

Sponsor: Texas A&M University · Participants: 100 · Started: Mar 4, 2022

Contact the study team

• Laura Ruebush, PhD · Phone: 979-422-1789
• Marielle Engelen, PhD · Phone: 979-422-1789

Official record on ClinicalTrials.gov — NCT05240885

Locations in the U.S.

From ClinicalTrials.gov, data retrieved Oct 2, 2026. Each study sets its own eligibility; the study team decides who can join.