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Cortical Excitability in Cyclic Vomiting Syndrome

Who can join

Ages 18 to 60 · All sexes · Healthy volunteers welcome

Inclusion Criteria:

* diagnosis of CVS

Exclusion Criteria:

* history of CVS (for healthy control population only)
* psychosis or altered cognitive status
* history of head injury, metal in the skull, stroke, or a history of seizures or a history of syncope (fainting or passing out)
* implantable devices, such as a pacemaker or nerve stimulator
* current use of the following medications or use of substances which are known to lower the seizure threshold: clozapine (Clozaril), chlorpromazine (Thorazine), amphetamines or methamphetamine, Ecstasy, Ketamine, Angel Dust/PCP, cocaine, or 3 or more alcoholic drinks per day
* pregnancy

About the study

This exploratory study will determine if there are differences in cortical excitability between patients suffering from cyclic vomiting syndrome (CVS) and healthy control subjects, as assessed by a non-invasive method of brain stimulation (Transcranial Magnetic Stimulation, TMS).

What is being tested

• TMS Paired-Pulse assessment of cortical excitability (other)
• Autonomic activity (other)

Sponsor: University of Pittsburgh · Participants: 110 · Started: May 16, 2022

Contact the study team

• Elijah D Wright · Phone: 412-647-1228
• David J Levinthal, MD PhD · Phone: 412-303-0525

Official record on ClinicalTrials.gov — NCT05256160

Locations in the U.S.

From ClinicalTrials.gov, data retrieved Oct 3, 2026. Each study sets its own eligibility; the study team decides who can join.