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Oxalate and Citrate
RecruitingHealthy volunteers welcome
Oxalate and Citrate in Humans
Who can join
Ages 18 to 70 · All sexes · Healthy volunteers welcome
Full eligibility criteria
Inclusion Criteria: Stone formers: * Age 18-70 * History of at least one calcium-based kidney stone Non-stone formers (controls): * Age 18-70 * No history of kidney stone * 24-hour urine oxalate within lab normal (\<50mg/day) Exclusion Criteria: * History of primarily uric acid, cysteine, or struvite stones. * History of severe acid-base abnormality, very low (less than 100mg/day) or very high (greater than 1500mg/day) urine citrate. * Any controls or stone-forming participants who cannot stop diuretic medication or alkali supplementation for the course of the study period. * Non-stone formers and stone-formers with extreme levels of urine citrate will be excluded from this small initial study to reduce heterogeneity and remove focus from the extremes of citrate levels.
About the study
This is a single-center study that aims to earn more about how two different compounds found in food, oxalate and citrate, may affect a person's chances of forming kidney stones.
What is being tested
- Kidney stones Normal controls Consuming a special drink (sodium oxalate) during an all day visit to the University of Chicago research clinic (other)
Sponsor: University of Chicago · Participants: 50 · Started: Oct 27, 2022
Contact the study team
Official record on ClinicalTrials.gov — NCT05334979
Locations in the U.S.
| Illinois | University of Chicago Medical Center, Chicago |
Conditions
From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.