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Oxalate and Citrate

RecruitingHealthy volunteers welcome

Oxalate and Citrate in Humans

Who can join

Ages 18 to 70 · All sexes · Healthy volunteers welcome

Full eligibility criteria
Inclusion Criteria:

Stone formers:

* Age 18-70
* History of at least one calcium-based kidney stone

Non-stone formers (controls):

* Age 18-70
* No history of kidney stone
* 24-hour urine oxalate within lab normal (\<50mg/day)

Exclusion Criteria:

* History of primarily uric acid, cysteine, or struvite stones.
* History of severe acid-base abnormality, very low (less than 100mg/day) or very high (greater than 1500mg/day) urine citrate.
* Any controls or stone-forming participants who cannot stop diuretic medication or alkali supplementation for the course of the study period.
* Non-stone formers and stone-formers with extreme levels of urine citrate will be excluded from this small initial study to reduce heterogeneity and remove focus from the extremes of citrate levels.

About the study

This is a single-center study that aims to earn more about how two different compounds found in food, oxalate and citrate, may affect a person's chances of forming kidney stones.

What is being tested

Sponsor: University of Chicago · Participants: 50 · Started: Oct 27, 2022

Contact the study team

Official record on ClinicalTrials.gov — NCT05334979

Locations in the U.S.

IllinoisUniversity of Chicago Medical Center, Chicago

Conditions

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.