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Personalized Perioperative Analgesia Platform (PPAP) for Cesarean Section

Who can join

Ages 18 and older · Women · Healthy volunteers welcome

Inclusion Criteria:

Adult women (\>18 yr) All races American Society of Anesthesiologists Classification (ASA) physical status: 1 to 3 undergoing elective Cesarean section that are willing to receive in-patient opioids.

Exclusion Criteria:

1. Health conditions including uncontrolled diabetes (gestational or pre-existing) or hypertension (pre-eclampsia, eclampsia, or chronic)
2. Any history of opioid misuse before or during pregnancy-per self-report and clinical notes
3. Preoperative severe pain and opioid use/misuse, allergy to oxycodone
4. Allergy to oxycodone
5. Significant neurological disorders, liver and renal diseases

About the study

The purpose of this collaborative CTSA (Clinical and Translational Science Award) application is to develop an innovative perioperative precision analgesia platform (PPAP) to improve analgesia and reduce serious immediate and long-term adverse outcomes of perioperative opioids in breastfeeding mothers and their infants

What is being tested

• Preoperative Genotyping (diagnostic test)

Sponsor: Senthil Sadhasivam · Participants: 700 · Started: Dec 5, 2022

Contact the study team

• Senthilkumar Sadhasivam, MD, MPH · Phone: 4126472994

Official record on ClinicalTrials.gov — NCT05380531

Locations in the U.S.

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.