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Persona MC vs PS RCT With ROSA

Randomized Control Trial Comparing Zimmer Biomet Persona Medial Congruent Versus Posterior Stabilized Total Knee Arthroplasty for Treatment of Knee Arthritis Using the ROSA Knee System

Who can join

Ages 18 and older · All sexes

Inclusion Criteria:

1. Patients ≥18 years of age
2. Patients scheduled an elective primary TKA for a diagnosis of osteoarthritis or inflammatory arthritis using the ROSA Knee System.
3. Patient is willing to cooperate and follow study protocol and visit schedule
4. Subject has access to a device is capable of pairing to the Apple Watch, supporting application updates and is compatible with the mymobility App.

Exclusion Criteria:

1. Patient is pregnant
2. Patient is unable to provide written consent
3. Revision TKA
4. History of prior infection in the affected knee
5. History of prior open surgery with significant hardware in place on the affected knee (i.e. prior distal femur or proximal tibia fracture or osteotomy)
6. Preoperative diagnosis of post-traumatic arthritis, avascular necrosis, or fracture

About the study

A randomized, controlled study comparing two total knee implant devices, Persona medial congruent (MC) vs posterior stabilized (PS). These surgeries will be performed using the ROSA robotic system. Patients will be followed up to 5 years.

What is being tested

• Zimmer-Biomet Persona Medial Congruent (MC) Bearing Design (device)
• Zimmer-Biomet Persona Posterior-Stabilized (PS) Bearing Design (device)

Sponsor: NYU Langone Health · Participants: 200 · Started: Sep 27, 2023

Contact the study team

• Vinay Aggarwal, MD · Phone: 202 250 0679
• Daniel Waren · Phone: 954 559 2251

Official record on ClinicalTrials.gov — NCT05391828

Locations in the U.S.

From ClinicalTrials.gov, data retrieved Oct 2, 2026. Each study sets its own eligibility; the study team decides who can join.