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Inhaled Isopropyl Alcohol for Treatment of Nausea

Inhaled Isopropyl Alcohol for the Treatment of Nausea in a Pediatric Emergency Department: A Open Label, Randomized Controlled Clinical Trial

Who can join

Ages 7 to 17 · All sexes · Healthy volunteers welcome

Inclusion Criteria:

* Patients with a chief complaint of nausea or vomiting
* Ages 7-178 years, both sexes
* Weight ≥ 15 kg
* Baxter Animated Retching Faces (BARF) nausea severity score ≥ 4/10

Exclusion Criteria:

* 1\. Require IV access
* Inability to breathe in/out through the nose
* Anosmia (self- or parental report)
* Allergy to isopropyl alcohol or ondansetron
* Current or history of alcohol abuse
* Inability to communicate feeling nauseous
* Inability to follow directions regarding taking deep breaths through the nose
* Known prolonged QT interval
* Pregnancy
* Received antiemetics within the last 8 hours
* Currently taking apomorphine

About the study

To determine the efficacy of inhaled isopropyl alcohol in treating nausea/vomiting among pediatric patients compared with the conventional ondansetron, or placebo treatment in a tertiary care pediatric emergency department.

What is being tested

• Inhaled Isopropyl Alcohol (other)
• Oral Ondansetron (drug)
• Inhaled Placebo (other)

Sponsor: State University of New York at Buffalo · Participants: 84 · Started: Apr 20, 2022

Contact the study team

• Haiping Qiao, MBBS, MS · Phone: 7163230055
• Alana Koehler, MD · Phone: 315576264

Official record on ClinicalTrials.gov — NCT05418244

Locations in the U.S.

Conditions

• Nausea and Vomiting

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.