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Thermodynamic Model of Hyperthermia in Humans Undergoing HIPEC

Development of a Computational, Thermodynamic Model of Intraabdominal Hyperthermia in Humans Undergoing HIPEC

Who can join

Ages 18 and older · All sexes

Inclusion Criteria:

* Adults (at least 18 years or older)
* Scheduled to undergo HIPEC surgery for abdominal cancer at HFH-Main

Exclusion Criteria:

* Pregnant females
* Minors
* Disease not amenable for treatment with HIPEC after surgical examination.

About the study

Hyperthermic Intraperitoneal Chemotherapy (HIPEC) is a well-established alternative for patients with peritoneal surface malignancies. Although HIPEC has a predetermined protocol to manage body temperature, the resultant bladder and core-body temperatures are highly variable and unstable in clinical practice. Such results highlight an incomplete understanding of the thermodynamic processes during HIPEC in humans.

Previous clinical and animal investigations have studied abdominal hyperthermia, but a full human model incorporating patient variables, heat delivery, and the impact of the circulatory system and anesthesia in HIPEC has not been established.

This project seeks to develop and validate a computational thermodynamic model using prospective real-world data from humans undergoing HIPEC surgery. It is hypothesized that by incorporating patient, anesthetic, and perfusion-related variables in a thermodynamic model, the temperatures inside and outside the abdomen during HIPEC can be predicted.

What is being tested

• Additional temperature monitoring/recording (other)

Sponsor: Henry Ford Health System · Participants: 30 · Started: Sep 22, 2022

Contact the study team

• Katherine Nowak, PhD · Phone: 313-771-7128

Official record on ClinicalTrials.gov — NCT05426928

Locations in the U.S.

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.