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Preoperative Corticosteroids in Autoimmune Thyroid Disease

Randomized Controlled Trial of Preoperative Corticosteroids in Autoimmune ThyroidDisease

Who can join

Ages 18 and older · All sexes

* Inclusion Criteria:

  ■ Graves' disease or Hashimoto's disease with positive thyroid autoantibodies (TgAb, TPO, TSI, and/or TRAb) undergoing total thyroidectomy for their disease.
* Exclusion Criteria:

  * Pediatric patients \< 18
  * Prior treatment with RAI
  * Prior neck surgeries
  * Known diagnosis of thyroid cancer
  * Diabetic patients on medications
  * A history of adverse reactions to corticosteroids.
  * Patients on any immunosuppressive regimen (such as organ transplant patients or patients treated for other autoimmune conditions). This includes patients with recent history of steroid therapy, or a history of adverse reactions to corticosteroids.

About the study

This study proposes to randomize patients about to undergo surgery for their autoimmune, inflammatory thyroid disease, and determine if a short course of corticosteroids decreases the inflammation of the gland and makes surgery less difficult.

What is being tested

• Dexamethasone (drug)
• Placebo (drug)

Sponsor: Indiana University · Participants: 76 · Started: Jun 16, 2023

Contact the study team

• Alexandria McDow, MD · Phone: 317-944-4377

Official record on ClinicalTrials.gov — NCT05435547

Locations in the U.S.

Conditions

• Graves Disease

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.