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Genomic Predictors of Recurrent Pregnancy Loss
RecruitingObservational studyHealthy volunteers welcome
Large Scale Genome Sequencing and Integrative Analyses to Define Genomic Predictors of Recurrent Pregnancy Loss
Who can join
Ages 18 to 50 · All sexes · Healthy volunteers welcome
Full eligibility criteria
Cohort A - Fetal Intolerome Cohort Inclusion Criteria: * Women with loss of a current singleton pregnancy at \< 20 0/7 weeks gestation, documented by ultrasonography or histopathological examination * History of one or more prior pregnancy losses * Euploid current pregnancy confirmed by karyotype, microarray, or STORK (Short-read Transpore Rapid Karyotyping) sequencing Note: A limited number of aneuploid losses will be included as part of the pilot phase Exclusion Criteria: * History of parental karyotype abnormalities * History of antiphospholipid antibody syndrome * Evidence of uncontrolled diabetes * Evidence of uncontrolled thyroid disease * History of autoimmune disease related to pregnancy loss (e.g., systemic lupus erythematosus, rheumatoid arthritis) * History of uterine anomalies * History of cervical insufficiency Cohort B - Maternal Effect Gene Cohort Inclusion Criteria: \- Women with a history of three or more pregnancy losses of unknown cause, with or without a liveborn child Exclusion Criteria: \- Known etiology for pregnancy loss
About the study
The overall goals of this proposal are to determine the genetic architecture of recurrent pregnancy loss (RPL) and to discover genomic predictors of RPL.
Sponsor: Yale University · Participants: 500 · Started: Sep 1, 2021
Contact the study team
- Yong-Hui Jiang, MD, PhD · Phone: 2037852429
- Heping Zhang, PhD · Phone: 12037855185
Official record on ClinicalTrials.gov — NCT05444283
Locations in the U.S.
From ClinicalTrials.gov, data retrieved Sep 29, 2026. Each study sets its own eligibility; the study team decides who can join.