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SV2A in Older Adults
RecruitingPhase 1/2Healthy volunteers welcome
Effect of Cannabis Use on Synaptic Density in Older Adults
Who can join
Ages 50 and older · All sexes · Healthy volunteers welcome
Full eligibility criteria
Inclusion Criteria: * Able to provide informed consent * Male or female, aged ≥50 years * No history of significant medical or neurological disease * BMI ≤ 50 * If woman of childbearing potential, must agree to use an acceptable method of birth control, as determined by the principal investigator, for the duration of the study and up to one month after completion of PET scans Exclusion Criteria: * Women with a positive pregnancy test or women who are lactating * Have had exposure to ionizing radiation that in combination with the study tracer would result in a cumulative exposure that exceeds recommended exposure limits; * History of a bleeding disorder or are currently taking anticoagulants * Subjects who have donated blood within 8 weeks of the present study
About the study
The aim of the study is to examine the effect of cannabis use on brain synaptic density among older adults using \[11C\]UCB-J PET imaging.
What is being tested
- [11C]UCB-J PET (drug)
Sponsor: Yale University · Participants: 24 · Started: Jul 6, 2022
Contact the study team
- Angerlyk Frytz, MD · Phone: 203-974-7822
Official record on ClinicalTrials.gov — NCT05465538
Locations in the U.S.
| Connecticut | Conneticut Mental Health Center, New Haven |
From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.