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The Impact of Removal of Exercise on Glycemic Control and Vascular Health in Older Active Adults
The Impact of Removal of Exercise on Glycemic Control and Vascular Health in Older Active
Who can join
All ages · All sexes · Healthy volunteers welcome
Full eligibility criteria
Inclusion Criteria: 1. 55 years and older, 18-40 years old 2. Healthy, physically active, performing at least 90 min/week of physical activity 3. Free of physical limitations that may interfere with alterations in daily physical activity levels Exclusion Criteria: 1. Physician diagnosed HIV, hepatitis, or tuberculosis. 2. Body weight change of greater than 5% within the previous 2 months 3. Smoking within the previous 2 months. 4. Taking medications that alter blood glucose levels
About the study
The purpose of this study is to determine if an acute bout of removal of exercise reduces enothelial function and glycemic control in an active, older adult population; and whether a 3 day return to exercise restores this response. Glycemic control is the blood glucose response following the consumption of a meal. It is an indicator of insulin resistance (or type 2 diabetes) and impaired glycemic control has been suggested to lead to cardiovascular disease. Endothelial function has been shown to be improved by chronic or acute increases in physical activity. Both of these have been shown to be impaired to acute bouts of inactivity in young populations; however the impact of acute inactivity in older adults is less understood. In this proposal the investigators will examine 1)how quickly impairments in glycemic control occur to acute physical inactivity in older adults who exercise, 2) how quickly impairments in endothelial function occur to acute inactivity in older adults who exercise, and 3) whether 3 days of a return to exercise restores these responses.
What is being tested
- removal of exercise (other)
Sponsor: Old Dominion University · Participants: 40 · Started: Jul 25, 2022
Contact the study team
- Leryn Reynolds · Phone: 757-683-4974
Official record on ClinicalTrials.gov — NCT05468255
Locations in the U.S.
| Virginia | Old Dominion University, Norfolk |
Conditions
From ClinicalTrials.gov, data retrieved Oct 2, 2026. Each study sets its own eligibility; the study team decides who can join.