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Ansa Cervicalis and Hypoglossal Nerve Stimulation in OSA

Ansa Cervicalis and Hypoglossal Nerve Stimulation in Obstructive Sleep Apnea

Who can join

Ages 18 and older · All sexes

Inclusion Criteria:

1. Consenting adults with BMI≥ 25 and ≤ 40 kg/m2
2. Obstructive sleep apnea with an AHI between 20 and 80 events/hr (with hypopneas defined by 4% oxyhemoglobin desaturations); ≥80% obstructive events.

Exclusion Criteria:

1. Chronic use of opiate medications, illicit drug use, or alcohol dependency
2. Other known concomitant sleep disorder (e.g., central sleep apnea, periodic limb movements, narcolepsy)
3. Clinical history or evidence of cardiopulmonary disease (or oxygen use), liver, renal, immunodeficiency, neurodegenerative diseases, or previous adverse reactions to anesthesia.
4. Prior upper airway reconstructive surgery excluding tonsillectomy (e.g., cleft palate repair, uvulopalatopharyngoplasty)
5. Indwelling neurostimulation device (e.g. cardiac pacemaker, spinal, vagal, or hypoglossal nerve stimulator)

About the study

Polysomnography (PSG) and drug-induced sleep endoscopy (DISE) are widely used diagnostic studies for assessing obstructive sleep apnea (OSA) severity and collapse patterns of the upper airway anatomy during sleep. Hypoglossal nerve stimulation (HNS) therapy for obstructive sleep apnea suffers from variable response at the level of the soft palate. The Investigators propose a study examining the physiologic effect of ansa cervicalis stimulation (ACS) alone and in combination with HNS during PSG and DISE.

What is being tested

• Grass S88 Muscle Stimulator (device)

Sponsor: Vanderbilt University Medical Center · Participants: 100 · Started: Nov 3, 2022

Contact the study team

• Katie Hartley-Estes, RPSGT · Phone: 615-875-9214
• Nicole L Jones, MS · Phone: 615-936-2807

Official record on ClinicalTrials.gov — NCT05501236

Locations in the U.S.

Conditions

• Obstructive Sleep Apnea

From ClinicalTrials.gov, data retrieved Oct 2, 2026. Each study sets its own eligibility; the study team decides who can join.