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Characterization of the Temporo-masseteric Nerve Block (TMNB) in Healthy Subjects
Non-randomized Pilot Study to Characterize Temporo-masseteric Nerve Block (TMNB) in
Who can join
Ages 18 to 64 · All sexes · Healthy volunteers welcome
Full eligibility criteria
Inclusion Criteria: * 18-64 years of age * All ethnicity * Male and female sex * Fluent in written/spoken English * Never been diagnosed with TMD * No significant history of orofacial pain * \<5 headaches/month in the 3 months before enrollment * No reported use of a nightguard or occlusal splint 'No' to all questions on self-administered questionnaire for TMD screening: * Pain in jaw or temple on either side of the face in the last 30 days * Stiffness or pain in jaw upon awakening in the last 30 days * Any pain increase/reduction in the jaw/temple region during the last 30 days with * Chewing hard or tough food * Opening mouth or moving jaw forward or to the side * Hold teeth together/clenching/grinding/chewing gum * Using the jaw during activities such as talking, kissing or yawning Exclusion Criteria: * Traumatic injury/ surgery on face or jaw \< 6 months * current orthodontic treatment * pregnant or nursing, * kidney failure or renal dialysis, * heart disease or heart failure, * uncontrolled chronic respiratory disease/ hypertension/ diabetes * history of * seizures * hyperthyroidism * drug or alcohol abuse * psychiatric disorder/conditions requiring hospitalization * chemotherapy/radiation
About the study
The proposed pilot study is aimed at preliminary characterization of the TMNB injection in 20 healthy volunteers. Assessment of bite-force distribution and surface electromyographic activity of the temporalis and the masseter muscles, at rest and clench, before and after unilateral TMNB injection, will be the primary outcome measures. Post-injection assessments will be performed at 30 minutes, 2 hours, and 2 weeks after the injection. Participants will be surveyed regarding their experience receiving the TMNB injection (secondary outcomes).
What is being tested
- Temporomasseteric Nerve Block (drug)
Sponsor: Rutgers, The State University of New Jersey · Participants: 20 · Started: Oct 10, 2022
Contact the study team
- Gayathri D Subramanian · Phone: 9739723418
Official record on ClinicalTrials.gov — NCT05507164
Locations in the U.S.
| New Jersey | Rutgers School of Dental Medicine, Newark |
Conditions
From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.