Rate of Total Joint Infection 90-day After Surgery Following Irrigation With Next Science No-Rinse Solution vs SOC Alone

Inclusion Criteria:

1. Adult that meets at least one of the below criteria at time of screening:

   * American Society of Anesthesiologists (ASA) 3 2
   * BMI \>35
   * Patient with functional limitations as a result of disease1:

     * Poorly treated hypertension
     * Poorly treated diabetes
     * Chronic renal failure
     * Bronchospastic disease
     * Disease with intermittent exacerbations
     * Stable angina
     * Implanted pacemaker
   * Known history as an active nicotine use (smoker)
   * Known history of uncontrolled diabetes mellitus (HgbA1C \> 7.0)
   * Known history of end stage organ disease
   * Known history of inflammatory arthritis and currently on rheumatological medication (DMARDs)
   * Known history of current active cancer treatment (chemotherapy)
   * Venous Disease (Surgical Risk Calculator from ACS-NSQIP)
   * Charleston Comorbidity Score \> 2
   * Elixhauser Score \>11
   * Age 65 or older
2. Subject is scheduled to primary joint replacement.
3. Subject is willing and able to comply with all study procedures including transportation to the study site for all scheduled visits and be available for the duration of the study.
4. Subject has understood, signed, and dated the informed consent form.

Exclusion Criteria:

1. Unable to provide signed and dated informed consent.
2. Unable or unwilling to comply with all study-related procedures.
3. Known history of allergic reaction to any of the study products or its components, including any products used for standard of care (such as dressings or any coverings)
4. Subject has contraindications to general anesthesia
5. Any subject positive for Covid-19 virus at time of surgical screening
6. Subjects have evidence of prolonged QT segment, per EKG.
7. Subjects from a vulnerable population, in accordance with 45 CFR 46 Subparts B, C, and D