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Cognition and Imaging With Tigertriever

RecruitingObservational study

COGNITIVE Study- Cognition and Imaging With Tigertriever

Who can join

Ages 18 to 75 · All sexes

Full eligibility criteria
Inclusion Criteria:

1. Patients admitted with large vessel occlusion (LVO) and treated with the Tigertriever, as indicated per the approved IFU.
2. Tigertriever was used as the first line treatment in the target vessel.
3. A signed informed consent.
4. Age 18-75 years (inclusive).
5. No known significant pre-stroke disability (pre-stroke mRS 0 or 1).

Exclusion Criteria:

1. Use of any other IA recanalization device prior to the Tigertriever in the target vessel, including aspiration catheter.
2. Evidence of acute brain hemorrhage on CT and/or MRI at admission.
3. Prior hemorrhage, stroke, thrombolysis, and/or endovascular therapy in the last 3 months.
4. Probable cerebral amyloid angiopathy.
5. Pre-stroke diagnosed dementia and/or prescribed cholinesterase inhibitors.
6. Pre-stroke diagnosed and/or currently treated major depression.
7. Pre-stroke learning or intellectual disability.
8. Anticipated inability to obtain 6-month follow-up assessments.

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About the study

The objective of the COGNITIVE Study is to evaluate whether successful reperfusion with Tigertriever is associated with cognitive benefit.

Sponsor: Rapid Medical · Participants: 424 · Started: Oct 28, 2024

Contact the study team

Official record on ClinicalTrials.gov — NCT05531461

Locations in the U.S.

CaliforniaUniversity of California, Los Angeles
University of California, Irvine, Orange
MichiganCorewell Health Research Institute, Grand Rapids
New YorkWestchester Medical Center, New York
Montefiore Medical Center The University Hospital for Albert Einstein College of Medicine, The Bronx
PennsylvaniaThe Hospital of the University of Pennsylvania, Philadelphia

Conditions

From ClinicalTrials.gov, data retrieved Nov 15, 2026. Each study sets its own eligibility; the study team decides who can join.