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Study of SGR-1505 in Mature B-Cell Neoplasms

RecruitingPhase 1

A Phase 1, Open-Label, Multicenter, Dose Escalation Study of SGR-1505 as Monotherapy in Subjects With Mature B-Cell Malignancies

Who can join

Ages 18 and older · All sexes

Full eligibility criteria
Inclusion Criteria:

* Subject must have a history of histologically or cytologically confirmed mature B-cell malignancy.
* Subject must have measurable or detectable disease according to the applicable disease-specific classification system and meet criteria for initiation of treatment.
* Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1.
* Life expectancy ≥ 12 weeks.

Exclusion Criteria:

* The subject is in need of immediate cytoreductive therapy (unless the patient has no remaining treatment choice with potential benefit).
* Subject has previous invasive malignancy in the last 2 years.
* Subject has a known allergy to SGR-1505 or excipients of SGR-1505.
* Subject has symptomatic or active CNS involvement of disease.
* Any other diseases, metabolic dysfunction, physical examination finding, or clinical laboratory finding that would place the participant at increased risk to the use of an investigational drug.

About the study

The purpose of this study is to evaluate safety and tolerability and to determine the maximum tolerated dose (MTD) or maximum administered dose (MAD) and/or recommended dose (RD) of SGR-1505.

What is being tested

Sponsor: Schrödinger, Inc. · Participants: 98 · Started: Apr 10, 2023

Contact the study team

Official record on ClinicalTrials.gov — NCT05544019

Locations in the U.S.

ArizonaBanner Health - MD Anderson Cancer Center, Gilbert
DelawareChristiana Care Hospital - Helen F Graham Cancer Center, Newark
FloridaNapa Research, Pompano Beach
MassachusettsBeth Israel Deaconess Medical Center, Boston
New JerseyRegional Cancer Care Associates, Hackensack
New YorkRoswell Park Comprehensive Cancer Center, Buffalo
Weill Cornell, New York
Montefiore Medical Center, The Bronx
North CarolinaDuke University, Durham
OhioGabrail Cancer & Research Center, Canton
The Ohio State University - The James Cancer Hospital, Columbus
OregonOregon Health and Science University - Knight Cancer Institute, Portland
Rhode IslandRhode Island Hospital, Providence
TexasUniversity of Texas Southwestern, Dallas
WashingtonFred Hutchinson Cancer Center, Seattle
WisconsinMedical College of Wisconsin, Milwaukee

Conditions

From ClinicalTrials.gov, data retrieved Sep 29, 2026. Each study sets its own eligibility; the study team decides who can join.