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Study of SGR-1505 in Mature B-Cell Neoplasms
RecruitingPhase 1
A Phase 1, Open-Label, Multicenter, Dose Escalation Study of SGR-1505 as Monotherapy in Subjects With Mature B-Cell Malignancies
Who can join
Ages 18 and older · All sexes
Full eligibility criteria
Inclusion Criteria: * Subject must have a history of histologically or cytologically confirmed mature B-cell malignancy. * Subject must have measurable or detectable disease according to the applicable disease-specific classification system and meet criteria for initiation of treatment. * Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1. * Life expectancy ≥ 12 weeks. Exclusion Criteria: * The subject is in need of immediate cytoreductive therapy (unless the patient has no remaining treatment choice with potential benefit). * Subject has previous invasive malignancy in the last 2 years. * Subject has a known allergy to SGR-1505 or excipients of SGR-1505. * Subject has symptomatic or active CNS involvement of disease. * Any other diseases, metabolic dysfunction, physical examination finding, or clinical laboratory finding that would place the participant at increased risk to the use of an investigational drug.
About the study
The purpose of this study is to evaluate safety and tolerability and to determine the maximum tolerated dose (MTD) or maximum administered dose (MAD) and/or recommended dose (RD) of SGR-1505.
What is being tested
- SGR-1505 (drug)
Sponsor: Schrödinger, Inc. · Participants: 98 · Started: Apr 10, 2023
Contact the study team
- Study Physician · Phone: +1 (503)-922-0158
Official record on ClinicalTrials.gov — NCT05544019
Locations in the U.S.
Conditions
- Non-Hodgkin Lymphoma
- Waldenstrom Macroglobulinemia
- Marginal Zone Lymphoma
- Follicular Lymphoma
- Hypertrophic Pyloric Stenosis
- Burkitt Lymphoma
- Plasmablastic Lymphoma
- Primary Effusion Lymphoma
- Mantle Cell Lymphoma
- Chronic Lymphocytic Leukemia
From ClinicalTrials.gov, data retrieved Sep 29, 2026. Each study sets its own eligibility; the study team decides who can join.