The Impact of Product Formulation on the Pharmacokinetics and Pharmacodynamics of Cannabis Edibles

Inclusion Criteria

* Have provided written informed consent.
* Be between the ages of 21 and 55.
* Be in good general health based on screening procedures (e.g., physical exam, medical history interview, vital signs, routine blood tests).
* Test negative for illicit drugs (including cannabis) and test negative for alcohol (0% BAC) at screening and before any study sessions.
* Not be pregnant or nursing (if female). All females must have a negative serum pregnancy test at the screening visit and a negative urine pregnancy test at admission for each session.
* Have prior experience using THC-dominant cannabis.
* Have a body mass index (BMI) in the range of 16 to 38 kg/m2.
* Have not donated blood in the past 30 days.

Exclusion Criteria

* Self-reported use of illicit drugs (e.g., amphetamine, cannabis, cocaine, methamphetamine, MDMA, LSD, ketamine, heroin, psilocybin, prescription medications not prescribed to the person) in the past 30 days.
* History of significant allergic reaction or significant hypersensitivity to cannabis or to any of the other ingredients in the study products.
* Current concomitant medication use that may interact with the study drug including inhibitors and inducers of CYP2CP and CYP3A4 as well as highly-protein bound drugs and drugs with a narrow therapeutic index such as warfarin, cyclosporine, and amphotericin B.
* History of or current evidence of a significant medical condition that, in the opinion of the investigator or medical staff, will impact the participant's safety or interfere with study outcomes.
* Evidence of current psychiatric condition (based on MINI for DSM-5).
* Been in treatment previously for cannabis use disorder.
* Receiving of any drug as part of a research study within the past 30 days.
* History of epilepsy or other serious medical condition.