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Improve Outcomes for Older Allogeneic Transplant Recipients

Intervening on Frailty to Improve Outcomes for Older Allogeneic Transplant Recipients

Who can join

Ages 60 and older · All sexes

Inclusion Criteria:

Cohort A (Prehab)

1. Age 60 years or older.
2. Planned allogeneic HCT in the next 1-6 months.
3. Hematological malignancy as the indication for HCT.
4. Pre-frail or frail by Fried frailty phenotype.

Cohort B (Rehab)

1. Age 60 years or older.
2. Planned allogeneic HCT or HCT within the last 30 days.
3. Hematological malignancy as the indication for HCT.

Exclusion Criteria:

Cohorts A and B

1\. Comorbid disability or illness that prevents safe exercise.

About the study

This is an interventional pilot study to determine whether implementation of a supervised exercise program can improve outcomes in subjects undergoing allogeneic HCT. The primary objective is to determine feasibility. Up to 60-72 evaluable subjects will be enrolled. Evaluable subjects are defined as those participating in the exercise intervention.

What is being tested

• Exercise Program (Cohort A Prehab) (behavioral)
• Exercise Program (Cohort B Rehab) (behavioral)

Sponsor: Abramson Cancer Center at Penn Medicine · Participants: 72 · Started: Feb 15, 2023

Contact the study team

• Jacqui Rick · Phone: 2152209675

Official record on ClinicalTrials.gov — NCT05612789

Locations in the U.S.

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.