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Changes of Soft Tissue Grafting: A Randomized Study

Volumetric Changes of Soft Tissue Grafting. Comparison of Autologous PRF (Platelet-rich Fibrin ) & Autogenous CTG (Connective Tissue Grafts) . A Split-mouth Randomized Design

Who can join

Ages 18 and older · All sexes

Inclusion Criteria:

1. Adults 18yrs or older
2. Need of MG-tx for 2 or more sites for root coverage RT I and II (Cairo classification)
3. Class A +/-
4. No class V restoration present

Exclusion Criteria:

1. Patients who do not consent to recommended therapy
2. Patients who smoke
3. Patients who will not be able to comply with follow up protocols
4. Those who self report that they are pregnant.

About the study

To correct gum recession, patient's own tissue from the roof of the mouth is harvested and placed where there is root exposed. This is considered gold standard of treatment. Sometimes patient don't want to have second surgical site in their mouth and at the same time do not want to use alternative tissue from human or animal donor. Using patients' blood and preparing it as a membrane is the next best thing to correct gum recession.

What is being tested

• Split Mouth Design (procedure)

Sponsor: Tufts University · Participants: 50 · Started: Jan 11, 2023

Contact the study team

• Tannaz Shapurian, DDM, MSc · Phone: 617.636. 6741
• Ann-Marie Jacobson · Phone: 6176363751

Official record on ClinicalTrials.gov — NCT05633511

Locations in the U.S.

Conditions

• Gingival Recession

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.