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Change in MAPSE During Treatment of Sepsis
Evaluation of Mitral Annulus Systolic Plane Excursion (MAPSE) in Emergency Department Patients With Sepsis
Who can join
Ages 18 and older · All sexes
Full eligibility criteria
Inclusion Criteria: * Diagnosis of Sepsis or Septic Shock Exclusion Criteria: * Age equal to or less than 17 * patient in the emergency department * Unable to perform POCUS exam due to medical necessity * Patients without sepsis * unable to obtain consent or have a legal representative consent
About the study
Patients with bloodstream infections (sepsis) have been found in prior studies to have infection-related heart dysfunction, even if they did not have preexisting heart problems. Factors related to the infection may cause the heart to not pump as well as it should, causing critical illness in the form of low blood pressure (shock) and heart failure. Ultrasound is frequently used in the emergency department to evaluate why a patient might have low blood pressure. Part of that evaluation may include obtaining ultrasound images and making measurements about how well or poorly the heart is pumping. The investigators will evaluate a certain measurement that relates to cardiac function, determine how it changes in patients before and after they are treated for septic shock. This will involve placing an ultrasound probe on the patient's chest, measuring the upward and downward movement of the mitral valve, the mitral annulus systolic plane excursion (MAPSE), and comparing the measurements before and after treatment is started. The investigators are attempting to determine if this measurement improves before and after treatment.
What is being tested
- Treatment of Sepsis (other)
Sponsor: University of Maryland, Baltimore · Participants: 50 · Started: Apr 1, 2023
Contact the study team
- Alexis Salerno, MD · Phone: (667) 214-2208
Official record on ClinicalTrials.gov — NCT05634733
Locations in the U.S.
| Maryland | University of Maryland Medical Center, Baltimore |
Conditions
From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.