Home › Social Anxiety Disorder › NCT05649059
Investigating the Effects of Cannabidiol on Social Anxiety Disorder
RecruitingPhase 4
Who can join
Ages 18 to 55 · All sexes
Full eligibility criteria
Inclusion Criteria: * Ability and willingness to provide written informed consent. * Sufficiently fluent in English to participate in the trial. * Between 18-55 years of age (inclusive). * Right-hand dominant. * Current medications are stable for past 30 days (no changes to dose or frequency). * Negative result on pregnancy test (if female). * Negative result on urine drug screening. * Liebowitz Social Anxiety Scale (LSAS ≥ 60). Exclusion Criteria: * History of bipolar disorder, schizophrenia, psychosis, delusional disorders. * History of eating disorder within past 6 months. * History of any traumatic brain injury. * Currently diagnosed with diabetes mellitus. * Presence of severe medical illness that would prevent completion of study procedures. * Presence of significant neurological illness or cognitive dysfunction (e.g.; seizures, dementia). * History of substance use disorder within past 6 months (other than nicotine and caffeine). * Use of any cannabis-containing products in past 30 days (CBD or THC). * Use of benzodiazepines in past 2 weeks. * Use of alpha- or beta-blockers in past week. * History of claustrophobia. * Contraindications for MRI (e.g.; shrapnel). * Presence of any other medical condition that, in the investigator's opinion, may interfere with the study procedures. * Use of concomitant medication that has a strong interaction with CBD. * History of liver disease. * History of hypersensitivity to cannabinoids. * History of hypersensitivity to sesame seed oil. * Currently breastfeeding (if female).
About the study
The purpose of this study is to test whether a single-dose of Epidiolex (cannabidiol) is associated with reduced psychological, physiological, and neuroimaging measures of anxiety in people diagnosed with social anxiety disorder (SAD).
What is being tested
- Cannabidiol (drug)
- Placebo (drug)
Sponsor: Massachusetts Institute of Technology · Participants: 50 · Started: Jul 10, 2025
Contact the study team
- Omar Rutledge, MS · Phone: 617-324-2898
Official record on ClinicalTrials.gov — NCT05649059
Locations in the U.S.
| Massachusetts | Massachusetts Institute of Technology, Cambridge |
Conditions
From ClinicalTrials.gov, data retrieved Oct 2, 2026. Each study sets its own eligibility; the study team decides who can join.