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Study of Transcranial Direct Current Stimulation to Treat Epilepsy

Pilot Study of Transcranial Direct Current Stimulation (tDCS) to Treat Epilepsy

Who can join

Ages 6 and older · All sexes

Inclusion Criteria

* Clinical diagnosis of generalized onset or focal epilepsy or sleep-related epileptic encephalopathy.
* Estimated to have at least 2 countable seizures per month or spike-wave index ≥50%.
* Has not had control with at least 2 anti-seizure medicines.
* Able to maintain a constant medication for duration of the study (rescue meds allowed).
* Subject or legally authorized representative is able to understand consent and keep a seizure diary in English.

Exclusion Criteria:

* A disease likely to progress over course of the study.
* Psychogenic non-epileptic seizures.
* Suicide attempt or psychiatric hospitalization past 2 years.
* A skin condition interfering with scalp electrodes or allergy to silver.
* Women will verify not pregnant, and if applicable, have a serum pregnancy test.
* Implanted devices (e.g. pacemakers)-except VNS, which is allowed.

About the study

The purpose of this research is to see to what extent electrical stimulation applied to the scalp (transcranial direct current stimulation or tDCS) can reduce the number and intensity of epileptic seizures.

What is being tested

• ActivaDose II 0.1 mA transcranial direct current stimulation (tDCS) (device)
• ActivaDose II 2.0 mA transcranial direct current stimulation (tDCS) (device)

Sponsor: Mayo Clinic · Participants: 30 · Started: Apr 12, 2023

Contact the study team

• Precylla Ruiz · Phone: 507-538-6606
• Izzie Meunier · Phone: 507-538-6337

Official record on ClinicalTrials.gov — NCT05673915

Locations in the U.S.

Conditions

• Partial Epilepsies

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.