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A Study to Analyze the Role of Sympathetic Nervous System in Spontaneous Coronary Artery Dissection

Role of the Neurovascular System in Spontaneous Coronary Artery Dissection (SCAD)

Who can join

Ages 18 and older · Women · Healthy volunteers welcome

Inclusion Criteria:

* For SCAD patients: history of SCAD as confirmed by coronary angiography or cardiac computed tomography angiography
* For controls: no cardiac disease history

Exclusion Criteria:

* Pregnancy
* Known or suspected unstable cardiac condition within 4 weeks of the study
* Active treatment with anticoagulation or dual antiplatelet therapy
* Prisoner

About the study

The purpose of this research is to compare sympathetic function (flight or fight system) and arterial health including structure and mechanics of participants with history of spontaneous coronary artery dissection (SCAD) to age and sex matched control participants.

What is being tested

• Arterial Tonometry (other)
• Echocardiogram (diagnostic test)
• Carotid Ultrasounds (diagnostic test)
• Elastography (diagnostic test)
• Ankle-Brachial Index (other)
• Microneurography with sympathoexcitatory maneuvers (other)

Sponsor: Mayo Clinic · Participants: 50 · Started: Jun 1, 2023

Contact the study team

• Pamela Engrav · Phone: 507-255-6938

Official record on ClinicalTrials.gov — NCT05699200

Locations in the U.S.

Conditions

• Spontaneous Coronary Artery Dissection

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.