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Striated Esophageal Motor Function Modulation in Health and Disease

Characterization of the Striated Esophagus (St.Eso) Deglutitive Motor Function and Its Modulation by Pharyngeal Phase Swallow Biomechanics

Who can join

Ages 18 to 90 · All sexes · Healthy volunteers welcome

Inclusion Criteria:

* Healthy subjects aged 18 to 90 years.
* Patents with dysphagia but normal high resolution esophageal manometric findings defined by the Chicago classification.

Exclusion Criteria:

* Anyone less than 18 years old.
* Patients with recent head and neck cancer (\<1 month post-surgery or \<3 months post-chemo radiation.
* Patients suffering from muscle diseases like muscular dystrophies, myopathies.
* Patients with neuro-muscular junction disorders myasthenia gravis, Eaton-Lambert disorders.
* Patients having history of allergy to lidocaine or barium.
* Patients who are pregnant or lactating.
* Patients who are medically unstable.
* Patients who are unable to apply the exerciser independently or with the help of a caregiver.
* Patients who lack cognition.

About the study

The investigators hypothesize that striated esophagus deglutitive motor function is modulated by pharyngeal phase swallowing biomechanics.

What is being tested

• Concurrent manometry/impedance and fluoroscopy with and without laryngeal restriction (device)
• Concurrent manometry/impedance and fluoroscopy before and after six weeks of using swallow muscle exercising device (device)

Sponsor: Medical College of Wisconsin · Participants: 557 · Started: Sep 13, 2022

Contact the study team

• Reza Shaker, MD · Phone: 4149556840
• Mark Kern · Phone: 4148053826

Official record on ClinicalTrials.gov — NCT05708885

Locations in the U.S.

Conditions

• Swallowing Disorders

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.