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UPURS Trial for Patient-centered Management of Symptomatic Obstructing Stones

Upfront vs Postponed Ureteroscopy (UPURS) Trial for Patient-centered Management of Symptomatic Obstructing Stones

Who can join

Ages 18 and older · All sexes · Healthy volunteers welcome

Inclusion Criteria:

* Presenting to the Emergency Department (ED)
* Adult (\> 18 yo)
* ≥5mm ureteral stone diagnosed on CT scan
* Presence of symptoms (pain, nausea, vomiting, hematuria)

Exclusion Criteria:

* Strict indication for stent
* Stone burden not amenable to Ureteroscopy (URS)
* Dirty urine analysis (UA) or positive urine culture (UCx)
* Transplant kidney
* Presence of conduit
* Comorbidities not optimized for surgery
* Strong preference for surgery or observation

About the study

A prospective, non-blinded, randomized controlled trial studying the management of symptomatic ureteral stones. This study will compare upfront ureteroscopy vs observation and delayed intervention for patients presenting to the emergency department with a symptomatic ureteral stone.

What is being tested

• Ureteroscopy (procedure)

Sponsor: University of California, San Francisco · Participants: 100 · Started: Sep 6, 2023

Contact the study team

• Heiko Yang, MD · Phone: 720-848-1800

Official record on ClinicalTrials.gov — NCT05715086

Locations in the U.S.

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.