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HEPA, PM2.5, and Cardiometabolic Health

RecruitingHealthy volunteers welcome

Using Indoor Air Filtration to Reduce PM2.5 Cardiometabolic Effects in At-risk Individuals

Who can join

Ages 65 to 84 · All sexes · Healthy volunteers welcome

Full eligibility criteria
Inclusion Criteria:

* Age between 65 and 84 years old;
* Nonsmoker for at least 1 year;
* History of BMI ≥ 25 kg/m2 in the past based on EMR information;
* Either an English or Spanish speaker;
* Live in the Los Angeles County.

Exclusion Criteria:

* History of diabetes (both type 1 and type 2) or degenerative disease of the nervous system (Alzheimer's disease or dementia);
* Currently have active cancer treatment;
* The residential house has already had HEPA filters;
* Participants will move out of the current house in the next 2 years;
* Participants will spend more than one month living outside the primary home;
* Have any health conditions that prohibit collecting health and covariate data and biospecimen;
* The residential houses are not feasible for setting up air purifiers and air pollutants monitors;
* Have high blood glucose from finger stick test (\> 200 mg/dL).

About the study

The goal of this randomized, double-blind, crossover trial is to test the hypothesis that a longer-term indoor HEPA filtration intervention can improve cardiometabolic profiles by reducing indoor PM2.5 exposures in at-risk individuals.

What is being tested

Sponsor: University of Southern California · Participants: 52 · Started: Mar 15, 2023

Contact the study team

Official record on ClinicalTrials.gov — NCT05718245

Locations in the U.S.

CaliforniaKeck School of Medicine, University of Southern California, Los Angeles

From ClinicalTrials.gov, data retrieved Oct 2, 2026. Each study sets its own eligibility; the study team decides who can join.