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HEPA, PM2.5, and Cardiometabolic Health
RecruitingHealthy volunteers welcome
Using Indoor Air Filtration to Reduce PM2.5 Cardiometabolic Effects in At-risk Individuals
Who can join
Ages 65 to 84 · All sexes · Healthy volunteers welcome
Full eligibility criteria
Inclusion Criteria: * Age between 65 and 84 years old; * Nonsmoker for at least 1 year; * History of BMI ≥ 25 kg/m2 in the past based on EMR information; * Either an English or Spanish speaker; * Live in the Los Angeles County. Exclusion Criteria: * History of diabetes (both type 1 and type 2) or degenerative disease of the nervous system (Alzheimer's disease or dementia); * Currently have active cancer treatment; * The residential house has already had HEPA filters; * Participants will move out of the current house in the next 2 years; * Participants will spend more than one month living outside the primary home; * Have any health conditions that prohibit collecting health and covariate data and biospecimen; * The residential houses are not feasible for setting up air purifiers and air pollutants monitors; * Have high blood glucose from finger stick test (\> 200 mg/dL).
About the study
The goal of this randomized, double-blind, crossover trial is to test the hypothesis that a longer-term indoor HEPA filtration intervention can improve cardiometabolic profiles by reducing indoor PM2.5 exposures in at-risk individuals.
What is being tested
- HEPA filter (device)
- Sham filter (device)
Sponsor: University of Southern California · Participants: 52 · Started: Mar 15, 2023
Contact the study team
- Zhanghua Chen, PhD · Phone: 323-442-2109
- Junfeng Zhang, PhD · Phone: 919-681-7782
Official record on ClinicalTrials.gov — NCT05718245
Locations in the U.S.
| California | Keck School of Medicine, University of Southern California, Los Angeles |
From ClinicalTrials.gov, data retrieved Oct 2, 2026. Each study sets its own eligibility; the study team decides who can join.