Targeting Breathing Limitations to Improve Functional Outcomes in HFpEF
Targeting Breathing Limitations to Improve Functional Outcomes in Heart Failure With Preserved Ejection Fraction (HFpEF)
Who can join
Ages 55 to 90 · All sexes · Healthy volunteers welcome
Full eligibility criteria
Inclusion Criteria: * signs and symptoms of heart failure * an ejection fraction \> 0.50; * objective evidence of diastolic dysfunction. elevated biomarkers (NT-proBNP \>300 ng/dl) or HF hospitalization * healthy volunteers Exclusion Criteria: * age \< 55 years * BMI \> 50 kg/m2 * Atrial fibrillation with poorly controlled heart rate * phosphodiesterase type 5 (PDE5) inhibitor use * severe valvular disease * severe Chronic obstructive pulmonary disease (COPD) * Chronic kidney disease (CKD) 4 or higher * any restriction of ambulation and mobility.
About the study
The overall purpose of this study is to investigate whether pulmonary limitations that increase the oxygen (O2) cost of breathing impact dyspnea on exertion (DOE) and peak exercise capacity in patients with HFpEF and obesity. As per investigator's hypothesis, obesity is likely a significant contributor to DOE and exercise intolerance in patients with HFpEF.
What is being tested
- HeO2 gas mixture (other)
- Room air gas mixture (other)
Sponsor: University of Texas Southwestern Medical Center · Participants: 78 · Started: Jul 1, 2023
Contact the study team
- Raksa B Moran, RN · Phone: 214-345-6574
- Jessica N Alcala, RN · Phone: 214-345-6574
Official record on ClinicalTrials.gov — NCT05723679
Locations in the U.S.
| Texas | UT Southwestern Medical Center, Dallas |
Conditions
From ClinicalTrials.gov, data retrieved Sep 29, 2026. Each study sets its own eligibility; the study team decides who can join.